The Effects of Exercise on the Psycho-cognitive Function of Brain-Derived Neurotrophic Factor (BDNF) in the Young Adults

  • Nur Izzati Umar Zaman Universiti Teknologi MARA
  • Mohd Zaki Salleh Universiti Teknologi MARA
  • Najihah Hanisah Marmaya Universiti Teknologi MARA
  • Haliza Hasan Universiti Teknologi MARA
  • Mokhtar Muhammad Universiti Teknologi MARA
  • Sahol Hamid Abu Bakar Universiti Teknologi MARA
  • Lay Kek Teh Universiti Teknologi MARA


The benefit of exercise in inducing brain-derived neurotrophic factor (BDNF) functions in relation to cognition had been reported. Nevertheless, the ambiguity remains with regards to the types of exercise and the duration of exercise required for one to have beneficial effects. In this study, we aimed to analyse the effects of varying modes of exercises and the duration required to improve BDNF functions, specifically in the young adults. The types of exercises evaluated in the meta-analysis include (1) single bout of acute aerobic exercise, (2) repeated and frequent sessions of aerobic exercise (program exercise) over a course of several weeks, and (3) resistance training. Only a single bout of acute aerobic exercise (z=4.92, p=0.00001) is sufficient to cause an increase in BDNF following exercise intervention, while program exercise (z=1.02, p=0.31) and resistance training (z=0.92, p=0.36) demonstrated inconsistencies, some exhibited significant increase in BDNF levels while others exhibited similar results with the control groups.


Antunes, B. M., Rossi, F. E., Teixeira, A. M., & Lira, F. S. (2020). Short-time high-intensity

exercise increases peripheral BDNF in a physical fitness-dependent way in healthy men. European

Journal of Sport Science, 20(1), 43–50.

Baird, J. F., Gaughan, M. E., Saffer, H. M., Sarzynski, M. A., Herter, T. M., Fritz, S. L., den

Ouden, D. B., & Stewart, J. C. (2018). The effect of energy-matched exercise intensity on brainderived neurotrophic factor and motor learning. Neurobiology of Learning and Memory, 156, 33–

Basso, J. C., & Suzuki, W. A. (2017). The effects of acute exercise on mood, cognition,

neurophysiology, and neurochemical pathways: a review. Brain Plasticity, 2(2), 127–

Cacialli, P., Palladino, A., & Lucini, C. (2018). Role of brain-derived neurotrophic factor during

the regenerative response after traumatic brain injury in adult zebrafish. Neural Regeneration

Research, 13(6), 941.

Calabrese, F., Rossetti, A. C., Racagni, G., Gass, P., Riva, M. A., & Molteni, R. (2014). Brainderived neurotrophic factor: a bridge between inflammation and neuroplasticity. Frontiers in

Cellular Neuroscience, 8, 430.

Cattaneo, A., Cattane, N., Begni, V., Pariante, C. M., & Riva, M. A. (2016). The human BDNF

gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders.

Translational Psychiatry, 6(11), e958--e958.

Chang, Y.-K., Alderman, B. L., Chu, C.-H., Wang, C.-C., Song, T.-F., & Chen, F.-T. (2017). Acute

exercise has a general facilitative effect on cognitive function: A combined ERP temporal

dynamics and BDNF study. Psychophysiology, 54(2), 289–

Chang, Y.-K., Labban, J. D., Gapin, J. I., & Etnier, J. L. (2012). The effects of acute exercise on

cognitive performance: a meta-analysis. Brain Research, 1453, 87–

Chaput, J.-P., Klingenberg, L., Rosenkilde, M., Gilbert, J.-A., Tremblay, A., & Sjödin, A. (2011).

Physical activity plays an important role in body weight regulation. Journal of Obesity,

Childs, E., & de Wit, H. (2014). Regular exercise is associated with emotional resilience to acute

stress in healthy adults. Frontiers in Physiology, 5,

Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., Horton,

E. S., Castorino, K., & Tate, D. F. (2016). Physical activity/exercise and diabetes: a position

statement of the American Diabetes Association. Diabetes Care, 39(11), 2065–

Cubeddu, A., Bucci, F., Giannini, A., Russo, M., Daino, D., Russo, N., Merlini, S., Pluchino, N.,

Valentino, V., & Casarosa, E. (2011). Brain-derived neurotrophic factor plasma variation during

the different phases of the menstrual cycle in women with premenstrual syndrome.

Psychoneuroendocrinology, 36(4), 523–530.

Cunha, C., Brambilla, R., & Thomas, K. L. (2010). A simple role for BDNF in learning and

memory? Frontiers in Molecular Neuroscience, 3, 1.

Dinoff, A., Herrmann, N., Swardfager, W., Liu, C. S., Sherman, C., Chan, S., & Lanctôt, K. L.

(2016). The effect of exercise training on resting concentrations of peripheral brain-derived

neurotrophic factor (BDNF): a meta-analysis. PloS One, 11(9),


Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev,

E., Gold, B., Goldman, D., Dean, M., & others. (2003). The BDNF val66met polymorphism affects

activity-dependent secretion of BDNF and human memory and hippocampal function. Cell,

(2), 257–269.

Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Heo, S., McLaren, M., Pence, B. D.,

Martin, S. A., Vieira, V. J., Woods, J. A., McAuley, E., & Kramer, A. F. (2010). Brain-derived

neurotrophic factor is associated with age-related decline in hippocampal volume. The Journal of

Neuroscience: The Official Journal of the Society for Neuroscience, 30(15), 5368–

Figueiredo, C., Antunes, B. M., Giacon, T. R., Vanderlei, L. C. M., Campos, E. Z., Peres, F. P.,

Clark, N. W., Panissa, V. L. G., & Lira, F. S. (2019). Influence of Acute and Chronic HighIntensity Intermittent Aerobic Plus Strength Exercise on BDNF, Lipid and Autonomic Parameters.

Journal of Sports Science & Medicine, 18(2), 359.

Goekint, M., De Pauw, K., Roelands, B., Njemini, R., Bautmans, I., Mets, T., & Meeusen, R.

(2010). Strength training does not influence serum brain-derived neurotrophic factor. European

Journal of Applied Physiology, 110(2), 285–293.

Håkansson, K., Ledreux, A., Daffner, K., Terjestam, Y., Bergman, P., Carlsson, R., Kivipelto, M.,

Winblad, B., Granholm, A.-C., & Mohammed, A. K. H. (2017). BDNF responses in healthy older

persons to 35 minutes of physical exercise, cognitive training, and mindfulness: associations with

working memory function. Journal of Alzheimer's Disease, 55(2), 645–

Helm, E. E., Matt, K. S., Kirschner, K. F., Pohlig, R. T., Kohl, D., & Reisman, D. S. (2017). The

influence of high intensity exercise and the Val66Met polymorphism on circulating BDNF and

locomotor learning. Neurobiology of Learning and Memory, 144, 77–

Hötting, K., Schickert, N., Kaiser, J., Röder, B., & Schmidt-Kassow, M. (2017). The effects of

acute physical exercise on memory, peripheral BDNF, and cortisol in young adults. Neural

Plasticity, 2016.

Hwang, J., Brothers, R. M., Castelli, D. M., Glowacki, E. M., Chen, Y. T., Salinas, M. M., Kim,

J., Jung, Y., & Calvert, H. G. (2016). Acute high-intensity exercise-induced cognitive

enhancement and brain-derived neurotrophic factor in young, healthy adults. Neuroscience

Letters, 630, 247–253.

Jeon, Y., K., & Ha, C. H. (2015). Expression of brain-derived neurotrophic factor, IGF-1 and

cortisol elicited by regular aerobic exercise in adolescents. Journal of Physical Therapy Science,

(3), 737–741.

Jeon, Y., K., & Ha, C. H. (2017). The effect of exercise intensity on brain-derived neurotrophic

factor and memory in adolescents. Environmental Health and Preventive Medicine, 22(1), 1–

Kim, Y. (2015). The effect of regular Taekwondo exercise on Brain-derived neurotrophic factor

and Stroop test in an undergraduate student. Journal of Exercise Nutrition & Biochemistry, 19(2),

Kimura, T., Kaneko, F., Iwamoto, E., Saitoh, S., & Yamada, T. (2019). Neuromuscular electrical

stimulation increases serum brain-derived neurotrophic factor in humans. Experimental Brain

Research, 237(1), 47–56.

Knaepen, K., Goekint, M., Heyman, E. M., & Meeusen, R. (2010). Neuroplasticity—exerciseinduced response of peripheral brain-derived neurotrophic factor. Sports Medicine, 40(9), 765–

la Rosa, A., Solana, E., Corpas, R., Bartrés-Faz, D., Pallàs, M., Vina, J., Sanfeliu, C., & GomezCabrera, M. C. (2019). Long-term exercise training improves memory in middle-aged men and

modulates peripheral levels of BDNF and Cathepsin B. Scientific Reports, 9(1), 1–

Lambert, C. P., & Evans, W. J. (2005). Adaptations to aerobic and resistance exercise in the

elderly. Reviews in Endocrine and Metabolic Disorders, 6(2), 137–

Lemos Jr, J. R., Alves, C. R., de Souza, S. B. C., Marsiglia, J. D. C., Silva, M. S. M., Pereira, A.

C., Teixeira, A. L., Vieira, E. L. M., Krieger, J. E., Negrão, C. E., & others. (2016). Peripheral

vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF

Val66Met polymorphism. Physiological Genomics, 48(2), 116–

Levinger, I., Goodman, C., Matthews, V., Hare, D. L., Jerums, G., Garnham, A., & Selig, S.

(2008). BDNF, metabolic risk factors, and resistance training in middle-aged individuals. Medicine

& Science in Sports & Exercise, 40(3), 535–541.

Lin, C.-Y., Hung, S.-Y., Chen, H.-T., Tsou, H.-K., Fong, Y.-C., Wang, S.-W., & Tang, C.-H.

(2014). Brain-derived neurotrophic factor increases vascular endothelial growth factor expression

and enhances angiogenesis in human chondrosarcoma cells. Biochemical Pharmacology, 91(4),


Lipsky, R. H., & Marini, A. M. (2007). Brain-derived neurotrophic factor in neuronal survival and

behavior-related plasticity. Annals of the New York Academy of Sciences, 1122(1), 130–

Miyamoto, T., Hashimoto, S., Yanamoto, H., Ikawa, M., Nakano, Y., Sekiyama, T., Kou, K.,

Kashiwamura, S.-I., Takeda, C., & Fujioka, H. (2018). Response of brain-derived neurotrophic

factor to combining cognitive and physical exercise. European Journal of Sport Science, 18(8),


Miyamoto, T., Kou, K., Yanamoto, H., Hashimoto, S., Ikawa, M., Sekiyama, T., Nakano, Y.,

Kashiwamura, S., Takeda, C., & Fujioka, H. (2018). Effect of neuromuscular electrical stimulation

on brain-derived neurotrophic factor. International Journal of Sports Medicine, 40(01), 5–

Nystoriak, M. A., & Bhatnagar, A. (2018). Cardiovascular effects and benefits of exercise.

Frontiers in Cardiovascular Medicine, 5, 135.

Oh, H., Lewis, D. A., & Sibille, E. (2016). The role of BDNF in age-dependent changes of

excitatory and inhibitory synaptic markers in the human prefrontal cortex.

Neuropsychopharmacology, 41(13), 3080–3091.

Roh, H.-T., Cho, S.-Y., Yoon, H.-G., & So, W.-Y. (2017). Effect of exercise intensity on

neurotrophic factors and blood-brain barrier permeability induced by oxidative--nitrosative stress

in male college students. International Journal of Sport Nutrition and Exercise Metabolism, 27(3),


Schiffer, T., Schulte, S., Hollmann, W., Bloch, W., & Strüder, H. K. (2009). Effects of strength

and endurance training on brain-derived neurotrophic factor and insulin-like growth factor 1 in

humans. Hormone and Metabolic Research, 41(03), 250–254.

Schmidt-Kassow, M., Schädle, S., Otterbein, S., Thiel, C., Doehring, A., Lötsch, J., & Kaiser, J.

(2012). Kinetics of serum brain-derived neurotrophic factor following low-intensity versus highintensity exercise in men and women. Neuroreport, 23(15), 889–

Schmidt-Kassow, M., Zink, N., Mock, J., Thiel, C., Vogt, L., Abel, C., & Kaiser, J. (2014).

Treadmill walking during vocabulary encoding improves verbal long-term memory. Behavioral

and Brain Functions, 10(1), 24.

Schmolesky, M. T., Webb, D. L., & Hansen, R. A. (2013). The effects of aerobic exercise intensity

and duration on levels of brain-derived neurotrophic factor in healthy men. Journal of Sports

Science & Medicine, 12(3), 502.

Seifert, T., Brassard, P., Wissenberg, M., Rasmussen, P., Nordby, P., Stallknecht, B., Adser, H.,

Jakobsen, A. H., Pilegaard, H., Nielsen, H. B., & others. (2010). Endurance training enhances

BDNF release from the human brain. American Journal of Physiology-Regulatory, Integrative and

Comparative Physiology, 298(2), R372--R377.

Szuhany, K. L., Bugatti, M., & Otto, M. W. (2015). A meta-analytic review of the effects of

exercise on brain-derived neurotrophic factor. Journal of Psychiatric Research, 60, 56–

Tsai, C.-L., Pan, C.-Y., Chen, F.-C., Wang, C.-H., & Chou, F.-Y. (2016). Effects of acute aerobic

exercise on a task-switching protocol and brain-derived neurotrophic factor concentrations in

young adults with different levels of cardiorespiratory fitness. Experimental Physiology, 101(7),


Wagner, G., Herbsleb, M., Cruz, F. de la, Schumann, A., Brünner, F., Schachtzabel, C., Gussew,

A., Puta, C., Smesny, S., Gabriel, H. W., & others. (2015). Hippocampal structure, metabolism

and inflammatory response after a 6-week intense aerobic exercise in healthy young adults: a

controlled trial. Journal of Cerebral Blood Flow & Metabolism, 35(10), 1570–

Wagner, G., Herbsleb, M., de la Cruz, F., Schumann, A., Köhler, S., Puta, C., Gabriel, H. W.,

Reichenbach, J. R., & Bär, K.-J. (2017). Changes in fMRI activation in anterior hippocampus and

motor cortex during memory retrieval after an intense exercise intervention. Biological

Psychology, 124, 65–78.

Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., & Liu, H. (2020). The Role of

BDNF on Neural Plasticity in Depression. Frontiers in Cellular Neuroscience, 14,

Zembron-Lacny, A., Dziubek, W., Rynkiewicz, M., Morawin, B., & Woźniewski, M. (2016).

Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and

inactive elderly men. Brazilian Journal of Medical and Biological Research,


How to Cite
Umar Zaman, N. I., Salleh, M. Z., Marmaya, N. H., Hasan, H., Muhammad, M., Abu Bakar, S. H., & Teh, L. K. (2021). The Effects of Exercise on the Psycho-cognitive Function of Brain-Derived Neurotrophic Factor (BDNF) in the Young Adults . Journal of Cognitive Sciences and Human Development, 7(1), 33-56.