Investigation of Sodium Benzoate and Potassium Sorbate in Anti-Diabetic Herbal Drugs

Authors

  • Nazmul Islam Department of Nutrition and Food Technology, Jashore University of Science and Technology, Jashore- 7408, Jashore, Bangladesh & Department of General Educational Development, Daffodil International University, Dhaka, Bangladesh
  • Md. Omar Faruque Department of Nutrition and Food Technology, Jashore University of Science and Technology, Jashore- 7408, Jashore, Bangladesh
  • Rausan Zamir Department of Chemistry, University of Rajshahi, Rajshahi- 6205, Rajshahi, Bangladesh

DOI:

https://doi.org/10.33736/jaspe.4544.2022

Keywords:

UV-Vis spectrophotometric method, sodium benzoate, potassium sorbate and anti- diabetic herbal drug

Abstract

The objective of the study was to assess sodium benzoate and potassium sorbate in some anti-diabetic herbal drugs (ADHDs) collected from local markets using UV-Vis spectrophotometric method. Analytes were measured in bulk and finished drug formulations at 224 nm for Sodium benzoate and 254.5 nm for potassium sorbate. The calibration curve obeyed Beer’s law in the range of 0-40 ppm for sodium benzoate and 0-50 ppm for potassium sorbate and passed the goodness of fit evaluation. Limit of detection, LOD and limit of quantification, LOQ for sodium benzoate was 0.13 pm and 0.40 ppm respectively. The limit of detection, LOD and limit of quantification country is unknown. To conclude, whether the herbal drugs are safe to consume in terms of preservatives, more assessment is required., LOQ for potassium sorbate were 0.28 pm and 0.85 ppm respectively. No samples crossed safety limits for sodium benzoate and potassium sorbate. Overall picture of preservative content in herbal drugs of the country is unknown and, in this study, we identified both preservatives in the drug samples. To conclude, whether the herbal drugs are safe to consume in terms of preservatives, more assessment is required.

References

Malik, A.K., Blasco, C. & Pico, Y. (2010). Liquid chromatography-mass spectrometry in food safety, Journal of Chromatography A, 1217 (25), 4018–4040. https://doi.org/10.1016/j.chroma.2010.03.015

Akter, S., Zubair, M.A., Khan, M.S.H., Bari, L., Huq, M.A. & Rashid, M.A. (2017). Identification and quantification of sodium benzoate in different brands of mango juices available in Tangail region, Bangladesh, Bangladesh Pharmaceutical Journal, 20(1), 20-26. https://doi.org/10.3329/bpj.v20i1.32089

Sankar, D.G., Babu, A.N., Rajeswari, A. & Krishna, M.V. (2009). RP- HPLC method for estimation of flucloxacillin magnesium and sodium benzoate in oral suspension, Asian Journal of Chemistry, 21 (8), 5843-5846. ISSN: 0970-7077

Hassouna, M.E.M., Abdelrahman, M.M. & Mohamed, M.A. (2017). Validation of a novel and sensitive RP- HPLC method for simultaneous determination of cefixime trihydrate and sodium benzoate in powder for oral suspension dosage form, Journal of Forensic Science and Criminal Investigation, 2(5). DOI: 10.19080/JFSCI.2017.02.555600.

The United States Pharmacopoeial Convention, Sodium benzoate NF Monograph. (2017). USP40- NF 35, 7876.

World Health Organization (WHO), 24 th May 2018.

Parle, M. & Bansal, N. (2006). Herbal medicines: are they safe? Nature Product Radiance, 5, 6–14. ISSN 0975-1092

Ingle, K.P., Deshmukh, A.G., Padole, D.A., Dudhare, M.S., Moharil, M.P. & Khelurkar, V.C. (2017). Phytochemicals: extraction methods, identification, and detection of bioactive compounds from plant extracts, Journal of Pharmacognosy and Phytochemistry, 6, 32–36. E-ISSN: 2278-4136

Azwanida, N.N. (2015). A review on the extraction methods use in medicinal plants, principle, strength, and limitation, Medicinal and Aromatic Plants Research Journals, 4, 196. DOI: 10.4172/2167-0412.1000196

Pandey, A. & Tripathi, S. (2014). Concept of standardization, extraction, and pre-phytochemical screening strategies for herbal drug, Journal of Pharmacognosy and Phytochemistry. 2, 115–9. ISSN 2278-4136

Doughari, J. H. (2012). Phytochemicals: extraction methods, basic structures and mode of action as potential chemotherapeutic agents (pp. 1-33). Rijeka, Croatia: INTECH Open Access Publisher. ISBN 978-953-51-0296-0

Alhusban, A. A., Ata, S. A., & Shraim, S. A. (2019). The safety assessment of toxic metals in commonly used pharmaceutical herbal products and traditional herbs for infants in Jordanian market. Biological trace element research, 187(1), 307-315. https://doi.org/10.1007/s12011-018-1367-1

ICH. (2005). The International Council for Harmonization of technical requirements for pharmaceuticals for human use (ICH), In Validation of Analytical Procedurers: Text and Methodology (Q2) R1, ICH, Geneva, Switzerland.

FDA- Guidance for Industry, Validation of Analytical Procedurers- Definition and Terminology Final Guidance, FDA, Silver Spring, MD, USA. (2010).

Nair, B. (2001). Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate. International Journal of Toxicology, 20, 23-50. https://doi.org/10.1080/10915810152630729

Carocho, M., Barreiro, Filomena & B.M., Ferreira, P.I. (2014). Adding molecules to food, Pros and cons: a review on synthetic and natural food additives. Comprehensive Reviews in Food Science and Food Safety. 13 (4), 377–399. https://doi.org/10.1111/1541-4337.12065

Lee, J.W. (2006). Fit-for-purpose method development and validation for successful biomarker measurement, Pharmaceutical Research, 23(2), 312-328. https://doi.org/10.1007/s11095-005-9045-3

Downloads

Published

2022-04-30

How to Cite

Islam, N., Faruque, M. O. ., & Zamir, R. (2022). Investigation of Sodium Benzoate and Potassium Sorbate in Anti-Diabetic Herbal Drugs. Journal of Applied Science &Amp; Process Engineering, 9(1), 1091–1100. https://doi.org/10.33736/jaspe.4544.2022

Issue

Vol. 9 No. 1 (2022): Journal of Applied Science & Process Engineering, Volume 9, Number 1, 2022

Section

Articles

License

Copyright Transfer Statement for Journal

1) In signing this statement, the author(s) grant UNIMAS Publisher an exclusive license to publish their original research papers. The author(s) also grant UNIMAS Publisher permission to reproduce, recreate, translate, extract or summarize, and to distribute and display in any forms, formats, and media. The author(s) can reuse their papers in their future printed work without first requiring permission from UNIMAS Publisher, provided that the author(s) acknowledge and reference publication in the Journal.

2) For open access articles, the author(s) agree that their articles published under UNIMAS Publisher are distributed under the terms of the CC-BY-NC-SA (Creative Commons Attribution-Non Commercial-Share Alike 4.0 International License) which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original work of the author(s) is properly cited.

3) For subscription articles, the author(s) agree that UNIMAS Publisher holds copyright, or an exclusive license to publish. Readers or users may view, download, print, and copy the content, for academic purposes, subject to the following conditions of use: (a) any reuse of materials is subject to permission from UNIMAS Publisher; (b) archived materials may only be used for academic research; (c) archived materials may not be used for commercial purposes, which include but not limited to monetary compensation by means of sale, resale, license, transfer of copyright, loan, etc.; and (d) archived materials may not be re-published in any part, either in print or online.

4) The author(s) is/are responsible to ensure his or her or their submitted work is original and does not infringe any existing copyright, trademark, patent, statutory right, or propriety right of others. Corresponding author(s) has (have) obtained permission from all co-authors prior to submission to the journal. Upon submission of the manuscript, the author(s) agree that no similar work has been or will be submitted or published elsewhere in any language. If submitted manuscript includes materials from others, the authors have obtained the permission from the copyright owners.

5) In signing this statement, the author(s) declare(s) that the researches in which they have conducted are in compliance with the current laws of the respective country and UNIMAS Journal Publication Ethics Policy. Any experimentation or research involving human or the use of animal samples must obtain approval from Human or Animal Ethics Committee in their respective institutions. The author(s) agree and understand that UNIMAS Publisher is not responsible for any compensational claims or failure caused by the author(s) in fulfilling the above-mentioned requirements. The author(s) must accept the responsibility for releasing their materials upon request by Chief Editor or UNIMAS Publisher.

6) The author(s) should have participated sufficiently in the work and ensured the appropriateness of the content of the article. The author(s) should also agree that he or she has no commercial attachments (e.g. patent or license arrangement, equity interest, consultancies, etc.) that might pose any conflict of interest with the submitted manuscript. The author(s) also agree to make any relevant materials and data available upon request by the editor or UNIMAS Publisher.

To download Copyright Transfer Statement for Journal, click here