@article{HENRY YUSUFU WAKAWA_FASIHUDDIN BADRUDDIN AHMAD_SALE MUSA PUKUMA_HENRY BULAMA_JAMIMAH MOHAMMED MALGWI_2022, title={Antibacterial and Antifungal Activities of Leaf Extract of Morinda elliptica}, volume={12}, url={https://publisher.unimas.my/ojs/index.php/BJRST/article/view/4875-291-%2896-100%29}, DOI={10.33736/bjrst.4875.2022}, abstractNote={<p>This work was designed to evaluate the antimicrobial potential of <em>Morinda elliptica</em> by determining the zone of growth inhibition of the leaf extract against selected bacterial and fungal strains. Antifungal and antibacterial properties of the extract at different concentrations (25, 50, 100, 250 and 500 μg/ml) were investigated after successive maceration in four solvents in order of increasing polarity [hexane (180 g), dichloromethane (342 g), ethyl acetate (471 g), and methanol (384)]. The agar disc diffusion method was used against selected human bacteria <em>Escherichia coli</em>, <em>Salmonella typhii</em>, <em>Staphylococcus aureus</em>, and the antifungal activity of the extract against <em>Aspergillus </em><em>brasiliences </em>and <em>A. flavus</em>. Zones of growth inhibition of the extract were then compared with the standard antibiotic chloramphenicol (500 μg/ml) for the antibacterial activity, and against nystatin (500 μg/ml) for antifungal activity. The result of the study showed a remarkable bactericidal activity of the plant extract against the test organisms<em> E. coli</em> (14.667 <u>+</u> 0.577) and <em>S. typhii</em> (13.667 <u>+</u> 0.577) with a weak activity against the growth of <em>S. aureus</em> as compared to standard (21.667 <u>+</u> 0.577) at 500 μg/ml. The result of the antifungal activity showed considerable activity of the plant extract against the growth of <em>A.</em><em> brasiliences </em>(11 <u>+</u> 0.1000) and weak activity against the growth <em>A. flavus</em> at 500 μg/ml. The findings of the study indicated that the leaf extract of <em>M. elliptica</em> is a reservoir of bioactive compounds. The compounds can be useful in the development of new pharmaceutical products that can be effective against human pathogenic strains <em>E. coli </em>and<em> S. typhii</em><em>. </em>This could serve as a lead for understanding a novel mechanism of action in future research activities.</p&gt;}, number={2}, journal={Borneo Journal of Resource Science and Technology}, author={HENRY YUSUFU WAKAWA and FASIHUDDIN BADRUDDIN AHMAD and SALE MUSA PUKUMA and HENRY BULAMA and JAMIMAH MOHAMMED MALGWI}, year={2022}, month={Dec.}, pages={96-100} }