Melaleuca cajuputi Powell Essential Oil: A Review of Botanical, Phytochemical and Pharmacological Properties
Melaleuca cajuputi Powell essential oil
Abstract
Melaleuca cajuputi Powell essential oil (MCEO) is widely used in Malay traditional medicine for the treatment of stomach cramps, cough, acne, insect bites, thrush problems and many more. The demand for medicinal applications of MCEO is gradually increasing among the Southeast Asian community. All information regarding MCEO was collected via internet sources such as Google Scholar, Elsevier, PubMed, Baidu Scholar, Web of Science and local books. Meta-analysis method was performed to identify all publications or relevant books regarding the MCEO range from 1998 to 2021. The main bioactive compounds of MCEO include terpenes, esters, aldehydes and alkenes. Scientific research on MCEO has revealed a wide range of pharmacological activities such as contact and fumigant toxicity, repellence, antibacterial activity and many more. The MCEO has a huge potential for pharmaceutical and nutraceutical applications, but comprehensive toxicity studies must be conducted to ensure their safety. Research on pharmacokinetics studies and potential drug interactions with standard-of-care medications is still limited, which calls for additional studies, particularly in humans. Further assessments and clinical trials should be performed before it can be integrated into medicinal practices.
References
Aldred, E.M., Buck, C. & Vall, K. (2009). Terpenes. In Aldred, E.M., Buck, C. & Vall, K. (eds.) Pharmacology: A Handbook for Complementary Healthcare Professionals. Edinburgh, Churchill Livingstone. pp. 167-74.
Bakar, A.A. (2020). Bioactivity evaluation of Melaleuca cajuputi (Myrtales: Myrtaceae) crude extracts against Aedes mosquito. Pertanika Journal of Tropical Agricultural Science, 43(3): 303-313.
Bakar, A.A., Sulaiman, S,, Omar, B. & Ali, R.M. (2009). Evaluation of Melaleuca cajuputi Powell (Family: Myrtaceae) extract in aerosol can against dengue vectors in the laboratory. Journal of Tropical Medicine and Parasitology, 32(2): 58-64.
Barzic, A.I. & Ioan, S. (2015). Antibacterial drugs - from basic concepts to complex therapeutic mechanisms of polymer systems. In Bobbarala, V. (ed.) Concepts, compounds and the alternatives of antibacterials. IntechOpen. DOI: 10.5772/60755
Bua, A., Molicotti, P., Donadu, M.G., Usai, D., Le, L.S., Thi, T.T.T, Viet, Q.T.N, Mauro, M., Marianna, U., Piero, S. & Stefania, Z. (2020). “In vitro” activity of Melaleuca cajuputi against mycobacterial species. Natural Product Research 34(10): 1494-1497.
Buckle, J. (2015). Basic plant taxonomy, basic essential oil chemistry, extraction, biosynthesis, and analysis. In Buckle, J. (Ed.) Clinical Aromatherapy:Essential Oils in Healthcare. Third Edition. St. Louis, Churchill Livingstone. pp. 37-72.
Conklin, D.J. & Bhatnagar, A. (2010). Aldehydes and cardiovascular disease. In McQueen, C.A. (Ed.) Comprehensive Toxicology. Second Edition. Amsterdam, The Netherlands, Elsevier. pp. 489-512.
Cox-Georgian, D., Ramadoss, N., Dona, C. & Basu, C. (2019). Therapeutic and medicinal uses of terpenes. In Joshee, N., Dhekney, S.A. and Parajuli, P. (eds.). Medicinal Plants: From Farm to Pharmacy. Springer, Cham. pp. 333-359.
da Rosa, A.V. & Ordóñez, J.C. (2022). Biomass. In da Rosa, A.V. & Ordóñez, J.C. (eds.) Fundamentals of Renewable Energy Processes. Fourth Edition. Oxford, Academic Press. pp. 577-628.
Daud, D., Gan, N., Ali, M.T.M. & Tawang, A. (2015). The effect of Melaleuca cajuputi methanolic leaves extract on body growth, puberty and sperm quality of juvenile male rats. Biotechnology An Indian Journal, 11(3): 115-119
Davis, R. (2003). Fumigants. In Caballero, B. (ed.) Encyclopedia of Food Sciences and Nutrition. Second Edition. Oxford: Academic Press. pp. 2821-2826.
De Colmenares, N., de Rodriguez, G., Prieto, A., Crescente, O. & Cabrera, L. (1998). Phytoconstituents and antimicrobial activity of Melaleuca leucadendron leaf essential oil from Venezuela. Ciencia, 6(2): 123-128.
Domokos, E.T., Mărghitaş, A.L., Dezmirean, D., Bobiş, O. & Urcan, A. (2019). World wide used traditional medicinal plants against Staphylococcus aureus strains. A review. Animal Science, 62(1): 213-224.
Doran, J.C. (1999). Cajuput oil. In Southwell, I. and Lowe, R. (eds.) Tea tree: The genus Melaleuca Cajuput oil. Netherlands, Halwood Academic Publishers. pp. 221-235.
Hammer, K.A., Carson, C.F. & Riley, T.V. (1999). Antimicrobial activity of essential oils and other plant extracts. Journal of Applied Microbiology 86(6): 985-990.
Hamoud, R., Sporer, F., Reichling, J. & Wink, M. (2012). Antimicrobial activity of a traditionally used complex essential oil distillate (Olbas® Tropfen) in comparison to its individual essential oil ingredients. Phytomedicine, 19(11): 969-976.
Jayakumar, M., Ramachandran, M., Krishnaveni, T., & Nattudurai, G. (2021). Toxicity and biochemical effects of essential oils of Anethum graveolens leaves and Melaleuca cajuputi Powell against Rhyzopertha dominica (F.) (Coleoptera: Bostrichidae). International Journal of Tropical Insect Science, 41(2): 945-951.
Kabir, A., Cacciagrano, F., Tartaglia, A., Lipsi, M., Ulusoy, H.I. & Locatelli, M. (2020). Analysis of monoterpenes and monoterpenoids. In Silva, A.S., Nabavi, S.F., Saeedi, M. and Naburi, S.M. (eds.) Recent Advances in Natural Products Analysis. Netherland, Elsevier. pp. 274-286.
Kavallieratos, N.G., Boukouvala, M.C., Ntalaka, C.T., Skourti, A., Nika, E.P., Filippo, M., Eleonora, S., Eugenia, M., Riccardo, P., Giulio, L., Cristiano, G. & Giovanni, B. (2021). Efficacy of 12 commercial essential oils as wheat protectants against stored-product beetles, and their acetylcholinesterase inhibitory activity. Entomologia Generalis, 41(4): 385-414. DOI: 10.1127/entomologia/2021/1255
Keereedach, P., Hrimpeng, K. & Boonbumrung, K. (2020). Antifungal activity of Thai cajuput oil and its effect on efflux-pump gene expression in fluconazole-resistant Candida albicans clinical isolates. International Journal of Microbiology, 4(2020): 5989206. DOI: 10.1155/2020/5989206
Ko, K., Juntarajumnong, W. & Chandrapatya, A. (2009). Repellency, fumigant and contact toxicities of Melaleuca cajuputi Powell against Sitophilus zeamais Motschulsky and Tribolium castaneum Herbst. Thai Journal of Agricultural Science, 42(1): 27-33.
McHardy, S.F., Wang, H.L., McCowen, S.V. & Valdez, M.C. (2017). Recent advances in acetylcholinesterase inhibitors and reactivators: an update on the patent literature (2012-2015). Expert Opinion on Therapeutic Patents, 27(4): 455-476.
Musta, R., Nurliana, L., Darlian, L. & Rudi, L. (2022). Kinetics study of antibacterial activity of cajuput oil (Melaleuca cajuputi) on Escherichia coli, Staphylococcus aureus, and Bacillus cereus. Current Applied Science and Technology, 22(3): 1-10.
My, T.T.A., Loan, H.T.P., Hai, N.T.T., Hieu, L.T., Hoa, T.T., Thuy, B.T.P., Quang, D.T., Nguyen T.T., Tran, T.V.A, Nguyen, T.X.D, Nguyen, T.T., Nguyen, V.H., Pham, V.T., Vo, V.T. & Nguyen, T.A.N. (2020). Evaluation of the inhibitory activities of COVID‐19 of Melaleuca cajuputi oil using docking simulation. ChemistrySelect, 5(21): 6312-6320. DOI: 10.1002/slct.202000822
Noor , A.A.M., Yusuf, S.M., Wahab, W.N.A.W.A., Adam, M.F.I.C. & Sul’ain, M.D. (2021). Evaluation on composition, antioxidant and toxicity of Melaleuca cajuputi leaves. Advances in Traditional Medicine, 21: 693-699.
Orchard, A., Sandasi, M., Kamatou, G., Viljoen, A. & van Vuuren, S. (2017). The in-vitro antimicrobial activity and chemometric modelling of 59 commercial essential oils against pathogens of dermatological relevance. Chemistry and Biodiversity, 14(1): e1600218. DOI: 10.1002/cbdv.201600218
Ouellette, R.J. & Rawn, J.D. (2015). Aromatic Compounds. In Ouellette, R.J. & Rawn, J.D. (eds.) Principles of Organic Chemistry, Boston: Elsevier. pp. 133-162.
Petrachaianan, T., Chaiyasirisuwan, S., Athikomkulchai, S. & Sareedenchai, V. (2019). Screening of acetylcholinesterase inhibitory activity in essential oil from Myrtaceae. Thai Journal of Pharmaceutical Sciences, 43(1): 63-68.
Richbart, S.D., Merritt, J.C., Nolan, N.A., Dasgupta, P. (2021). Acetylcholinesterase and human cancers. In Tew, K.D. & Fisher, P.B. (eds.) Advances in Cancer Research. Cambridge, Massachusetts, Academic Press. pp. 1-66.
Roszaini, K., Azah, M.N., Mailina, J., Zaini, S. & Faridz, Z.M. (2013). Toxicity and antitermite activity of the essential oils from Cinnamomum camphora, Cymbopogon nardus, Melaleuca cajuputi and Dipterocarpus spp. against Coptotermes curvignathus. Wood Science and Technology, 47(6): 1273-1284.
Samuel, T.M., Zhou, Q., Giuffrida, F., Munblit, D., Verhasselt, V. & Thakkar, S.K. (2020). Nutritional and non-nutritional composition of human milk is modulated by maternal, infant, and methodological factors. Frontiers in Nutrition, 7: 576133. DOI: 10.3389/fnut.2020.576133
Septiana, S., Bachtiar, B.M., Yuliana, N. & Wijaya, C. (2019). Cajuputs candy impairs Candida albicans and Streptococcus mutans mixed biofilm formation in vitro. F1000Research 8:1923. DOI: 10.12688/f1000research.20700.2
Sfeir, J., Lefrançois, C., Baudoux, D., Derbré, S. & Licznar, P. (2013). In vitro antibacterial activity of essential oils against Streptococcus pyogenes. Evidence-Based Complementary and Alternative Medicine, 2013: 269161.
Susanto, M., Doran, J., Arnold, R. & Rimbawanto, A. (2003). Genetic variation in growth and oil characteristics of Melaleuca cajuputi subsp. cajuputi and potential for genetic improvement. Journal of Tropical Forest Science, 15(3): 469-482.
Szelényi, M., Erdei, A., Jósvai, J., Radványi, D., Sümegi, B., Vétek, G, Molnár, B.P. & Kárpáti, Z. (2020). Essential oil headspace volatiles prevent invasive box tree moth (Cydalima perspectalis) oviposition-insights from electrophysiology and behaviour. Insects, 11(8): 465. DOI: 10.3390/insects11080465
Tan, P., Corlett, R. & Tan, H. (2010). A field guide to the native garden@ HortPark: An urban oasis of the native flora and fauna of Singapore. Centre for Urban Greenery and Ecology and the National University of Singapore, Singapore.
Tawatsin, A., Asavadachanukorn, P., Thavara, U., Wongsinkongman, P., Bansidhi, J., Boonruad, T., Chavalittumrong, P., Soonthornchareonnon, N., Komalamisra, N. & Mulla, M.S. (2006). Repellency of essential oils extracted from plants in Thailand against four mosquito vectors (Diptera: Culicidae) and oviposition deterrent effects against Aedes aegypti (Diptera: Culicidae). Southeast Asian Journal of Tropical Medicine and Public Health, 37: 915.
Trinh, N.T.H., Anh, T.N.P. & Rappelli, P. (2021). Evaluation of the susceptibility of Trichomonas vaginalis isolates to Melaleuca cajuputi. International Journal of Multidisciplinary Research and Publications, 3(8): 1-4.
Wibowo, M.A., Sari, D.N., Jayuska, A. & Ardiningsih, P. (2021). Komposisi kimia dan uji aktivitas antibakteri minyak atsiri daun kayu putih (Melaleuca cajuputi) dari Kota Singkawang. Biopropal Industri, 12(1): 1-7.
Wijaya, C.H., Sari, B.R. & Bachtiar, B.M. (2020). The potency of cajuputs candy in maintaining the competitive capacity of Streptococcus sanguinis upon Streptococcus mutans. Journal of Functional Food and Nutraceutical, 1(2): 55-65. DOI:10.33555/jffn.v1i2.29
Wiliams, C. (2011). Medicinal plants in Australia Volume 2: Gums, resins, tannin and essential oils. Rosenberg Publishing Pty Ltd.
Yuan, H., Ma, Q., Ye, L. & Piao, G. (2016). The traditional medicine and modern medicine from natural products. Molecules, 21(5): 559. DOI: 10.3390/molecules21050559
Zainon, M.S., Nurul Jannah, J., Saifuddin, N. & Alifah Farhana, K. (2019). Laboratory evaluation of the efficacy of insect repellent products extracted from Melaleuca cajuputi Powell against mosquito. International Journal of Advanced Science and Technology, 28(10): 398-405.
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